| Display Channel | Digital Channel | Call Sign | Network | Nickname | Hours | Notes |
| W50CH-D | ALTON, IL | |||||
| 01-1 | 50.1 | W50CH | Religious | |||
| KTVI | ST. LOUIS, MO | |||||
| 02-1 | 43.3 | KTVI-DT | FOX | "Fox 2" | ||
| 02-2 | 43.4 | ANTENNA | Antenna TV | |||
| 02-3 | 43.5 | ESCAPE | Escape | |||
| KMOV | ST. LOUIS, MO | |||||
| 04-1 | 24.1 | KMOV-HD | CBS | "News 4 St. Louis" | ||
| 04-2 | 24.2 | KMOV-Me | COZI TV | |||
| 04-3 | 24.3 | KMOV-My | MyN | "MyTV St. Louis" | ||
| KSDK | ST. LOUIS, MO | |||||
| 05-1 | 35.3 | KSDK-5 | NBC | "NewsChannel 5" | ||
| 05-2 | 35.4 | Bounce | Bounce TV | |||
| 05-3 | 35.5 | Justice | Justice Network | |||
| 05-4 | 35.6 | Quest | Quest | |||
| KPTN-LD | ST. LOUIS, MO | |||||
| 07-1 | 19.1 | HSN | HSN | |||
| 07-2 | 19.2 | SBN | SonLife | |||
| 07-3 | 19.3 | QVCPlus | QVC2 | |||
| 07-4 | 19.4 | FRONT | Infomercials | |||
| 07-5 | 19.5 | BEAUTY | Beauty iQ | |||
| 07-6 | 19.6 | ONTV4U | Infomercials | |||
| 07-7 | 19.7 | Jewelry | Jewelry TV | |||
| KETC | ST. LOUIS, MO | |||||
| 09-1 | 23.3 | KETC-HD | PBS | "KETC 9" | ||
| 09-2 | 23.4 | KETCKid | PBS Kids 24/7 | "KETC Kids" | ||
| 09-3 | 23.5 | WORLD | World Channel | "KETC World" | ||
| 09-4 | 23.6 | KETCDIY | Create | "KETC Create" | ||
| KPLR-TV | ST. LOUIS, MO | |||||
| 11-1 | 26.3 | CW11-DT | CW | "KPLR 11" | ||
| 11-2 | 26.4 | THISTV | This TV | |||
| 11-3 | 26.5 | COMET | Comet TV | |||
| WPXS | MOUNT VERNON, IL | |||||
| 13-1 | 21.2 | Daystar | Daystar | |||
| 13-2 | 21.1 | RTV | Retro TV | |||
| KDTL-LD | ST LOUIS, MO | |||||
| 16-1 | 16.2 | KDTL | Retro TV | |||
| KEFN-CD | ST. LOUIS, MO | |||||
| 20-1 | 20.1 | KEFN-CD | EWTN | |||
| 20-2 | 20.2 | KEFN-CD | ||||
| KNLC | ST. LOUIS, MO | |||||
| 24-1 | 14.3 | KNLC-HD | Me-TV | |||
| 24-2 | 14.4 | NLEC TV | Religious | "NLEC TV" | ||
| 24-3 | 14.5 | Heroes | Heroes & Icons | |||
| 24-4 | 14.6 | Movies | Movies! | |||
| 24-5 | 14.7 | Decades | Decades | |||
| 24-6 | 14.8 | Start TV | ||||
| K25NG-D | ST. LOUIS, MO | |||||
| 25-1 | 25.1 | K25NG-D | 3ABN | |||
| 25-2 | 25.2 | 3ABN-PR | [Blank] | |||
| 25-3 | 25.3 | 3ABN-DD | ||||
| 25-4 | 25.4 | 3ABN-ES | [Blank] | |||
| 25-5 | 25.5 | 3ABN-RD | 3ABN Radio | |||
| 25-6 | 25.6 | 3ABN-RL | 3ABN Radio Latino | |||
| 25-7 | 25.7 | Radio74 | Radio 74 | |||
| W29CI-D | SALEM, IL | |||||
| 29-1 | 29.3 | W29CI-D | 3ABN | |||
| 29-2 | 29.4 | 3ABN-PR | 3ABN Proclaim | |||
| 29-3 | 29.5 | 3ABN-DD | 3ABN Dare to Dream | |||
| 29-4 | 29.6 | 3ABN-ES | 3ABN Latino | |||
| 29-5 | 29.7 | 3ABN-RD | 3ABN Radio | |||
| 29-6 | 29.8 | 3ABN-RL | 3ABN Radio Latino | |||
| 29-7 | 29.9 | Radio74 | Radio 74 | |||
| KDNL-TV | ST. LOUIS, MO | |||||
| 30-1 | 31.3 | KDNL-DT | ABC | "ABC 30" | ||
| 30-2 | 31.4 | TBD-TV | TBD | |||
| 30-3 | 31.5 | CHARGE! | Charge! | |||
| 30-4 | 31.6 | STADIUM | Stadium | |||
| KBGU-LP | ST. LOUIS, MO | |||||
| 33-1 | 33.1 | KBGU-LD | BUZZR | |||
| 33-2 | 33.2 | KBGU-LD | Shop LC | |||
| 33-3 | 33.3 | KBGU-LD | GetTV | |||
| 33-4 | 33.4 | KBGU-LD | Laff | |||
| 33-5 | 33.5 | KBGU-LD | QVC2 | |||
| 33-6 | 33.6 | KBGU-LD | CBN News | |||
| 33-7 | 33.7 | KBGU-LD | Grit | |||
| K38HD-D | ST. LOUIS, MO | |||||
| 38-1 | 38.1 | K38HD-D | HSN | |||
| WODK-LD | SPRINGFIELD, IL | |||||
| 45-1 | 45.1001 | WODK-LD | Infomercials | |||
| 45-2 | 45.1002 | WODK-LD | Infomercials | |||
| 45-3 | 45.1003 | WODK-LD | Infomercials | |||
| 45-4 | 45.1004 | WODK-LD | Infomercials | |||
| 45-5 | 45.1005 | WODK-LD | Stadium | |||
| 45-6 | 45.1006 | WODK-LD | Tuff TV | |||
| 45-7 | 45.1007 | WODK-LD | Evine Live | |||
| WRBU | EAST ST. LOUIS, IL | |||||
| 46-1 | 47.3 | ION | ION | |||
| 46-2 | 47.4 | qubo | Qubo | |||
| 46-3 | 47.5 | IONLife | ION Life | |||
| 46-4 | 47.6 | Shop | Infomercials | |||
| 46-5 | 47.7 | QVC | QVC | |||
| 46-6 | 47.8 | HSN | HSN | |||
| KDTL-LD | ST LOUIS, MO | |||||
| 51-1 | 16.1 | KUMO | Daystar | |||
| KUMO-LD | ST LOUIS, MO | |||||
| 51-1 | 51.1 | KUMO-LD | Daystar | |||